Shock Therapy™ Ingredients
Tyrosol is one of the major components of virgin olive oil. In addition to being delicious, virgin olive oil is well known as being healthy – and, Tyrosol is one of the big reasons why. For our purposes, its potent antimicrobial activity, particularly against pathogenic and otherwise unwanted bacteria, is of primary importance.
At just 10uM, Tyrosol produced 50% inhibition of Pseudomonas aeruginosa. Perhaps more importantly, it is quorum sensing (which means it notices and responds to an increase in growth and density of bacteria), and it inhibits the production of virulence factors (molecules that aid in colonization of host by pathogenic bacteria). It did not affect the bacterial wall, as many natural anti-bacterials do (35). This differing mechanism is likely why it was found to be synergistic with a number of other natural anti-bacterial compounds (36).
Tyrosol has been found to possess anti-bacterial action as potent as synthetic commercial disinfectants (37). Maybe more impressive, it is as potent as several pharmaceutical antibiotics such as gentamicin, amikacin, and ciprofloxacin (38). Finally, it has displayed efficacy over a very wide range of bacterial strains, which is perfect given that there are 1000s of strains in the gut (39).
Menthol is best known for its use in cold and nasal relief products, as well as muscle balms. It has that icy, minty smell.
It shows very robust antibacterial activity, being more effective than pharmaceutical antibiotic streptomycin against a wide array of bacteria (40). In fact, it is almost twice as potent as streptomycin against many of them (41).
Its antimicrobial activity appears to be mostly due to the ability to disrupt bacterial membrane structure and function (42). The mechanism being a perturbation of the lipid fraction of the microorganism’s plasma membrane, resulting in increased permeability and leakage of intracellular materials out of the cell (43). Basically, it cuts them open, and their guts fall out. This membrane disruption also renders the bacteria vulnerable to other antibiotics, for a synergistic effect (44).
Circumin is the spicy component of mustard seed as well as turmeric. It displays interesting mechanisms of action as well as strong potency at around 7-60 ug/ml on a number of bacterial species (45). It was effective at 20ug/ml with several additional species, inhibiting biofilm formation by 80% at this concentration (46). Most interestingly, it also disrupts bacterial cytokinesis, the physical process of cell division, in the low micromolar range, with a dissociation constant of just 7.3+/-1.8 uM (47). In other words, it keeps them from reproducing and does so effectively.
The most potent and most interesting anti-bacterial of all is Hyperforin, a component of St. John’s Wort. It is an extremely, extremely impressive anti-bacterial. It is effective at concentration as low as 100 ng/ml against Staph. This is considerably more potent than many pharmaceutical antibiotics -- we’re talking 10-100 fold more (48). It has been shown effective at .1-1 ug/ml on numerous other bacterial species (49).
As ultra-potent as it is, it also works by an unusual mechanism, stimulating natural host defense reactions, such as enhancement of phagocyte functions and elimination of bacterial breakdown products that would otherwise promote virulence. For this reason, it is considered an extremely promising compound in situations of antibiotic resistance such as with MRSA and for AIDS patients (50).
Finally, we come to Zingerone, a component of ginger, which is not terribly potent on its own with an MIC of 1-2mM (51). Its value is as an adjunct ingredient, potentiating the effects of our other antibiotics, by interfering with several processes of bacterial growth and colonization.
It inhibits the formation of biofilms that allow bacteria to adhere to the cell wall and form a barrier that protects them from antibiotics and phagocytosis from the immune system (52). Further, it silences quorum sensing, the process by which bacteria release molecules signaling colonization when a sufficient density it achieved. It also reduces the production of numerous virulence factors which allow the pathogen to do such things attach to cell walls, move around, evade immunity, and derive nutrition from the host (53).
Basically, it just terrorizes them at all levels. Kills their livestock, poisons their wells, burns down their houses, and absconds with their children. In combination with a wide array of other antibiotics, it was found to decrease minimum inhibitory concentrations needed by 2 to 8-fold (54).
All in all, Shock Therapy™ gives you 5 highly effective natural anti-bacterials, working synergistically through just about every mechanism possible. Invasive, enemy combatant bacteria do not have a chance. But, just as antibiotics do not get rid of an infection on the first day, they won’t destroy the bad bacteria in your gut immediately.
But, not to worry, several ingredients in Shock Therapy™ also have properties which are immediately ameliorative and healing. So, they will already be providing relief and working on several fixes in the gut while the anti-bacterials are getting your renegade microbiota under control.
See "Full Science Write-up" here http://neobium.org/product-line/shock-therapy/#1 for references.