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  2. Trump

    Turning and turning in the widening gyre The falcon cannot hear the falconer; Things fall apart; the centre cannot hold; Mere anarchy is loosed upon the world, The blood-dimmed tide is loosed, and everywhere The ceremony of innocence is drowned; The best lack all conviction, while the worst Are full of passionate intensity. Surely some revelation is at hand; Surely the Second Coming is at hand. The Second Coming! Hardly are those words out When a vast image out of Spiritus Mundi Troubles my sight: somewhere in sands of the desert A shape with lion body and the head of a man, A gaze blank and pitiless as the sun, Is moving its slow thighs, while all about it Reel shadows of the indignant desert birds. The darkness drops again; but now I know That twenty centuries of stony sleep Were vexed to nightmare by a rocking cradle, And what rough beast, its hour come round at last, Slouches towards Bethlehem to be born?
  3. The intention is for initial comments and discussion to be on the blog, itself. But, since blog posts do not get bumped like forum posts, this is for ongoing discussion after a day or two. http://www.avantlabs.com/forum/blog/7/entry-4-shock-therapy-tm-part-1/
  4. Shock Therapy (tm) -- Part 1

    Shock Therapy™ Microbiotic Rebirth™ There are trillions of bacteria, living and breeding inside your body, right now. You need some of them to survive, but many of them hate you. For most people, due to genetics and/or diet, the evil ones have gotten the upper hand, attacking you with not only fat gain, but whole body inflammation accompanied by damage to insulin sensitivity, cardiovascular and digestive health, the immune system, and even your skin and brain. Shock Treatment™ combines 5 potent, natural antibiotics to seek out and destroy them, freeing the kingdom of your gut to be repopulated with loyal, benevolent bacterial citizens. Introduction Currently, probiotics are mostly thought of and used in relation to a healthy digestive system (reducing upset stomach, gas and bloating, diarrhea, and IBS type symptoms) and the immune system (coughs, colds, and general sinus and respiratory health). While they certainly are indeed useful for such applications, the ramifications of an unhealthy gut and microbiota go far, far beyond that. The gut and its microbiome are essentially a massive endocrine organ, controlling and influencing basically your entire body and brain. And, given that all of the trillions of bacteria that call it home originally came from outside your body – and entered without your permission – it is by far the most important organ in which we can take steps to manipulate and take back control. We will first look at some basic science and data on how this all works. Then, we will look at studies that have shown alterations in the microbiotic make-up of the gut, and the correlations they display in health and disease, suboptimal and optimal fitness, and just general things that everyone would consider part of good or bad life outcomes. It is a massive subject, far too much to discuss in complete depth, here, so we’ll do our best to keep it as short and sweet as possible while still giving you enough background in this field to understand the shocking reality, scope, and importance of this microscopic invasion. Subsequently, we will get down to business and specifically get into the science of Shock Treatment™, the first step in the process of making yourself king or queen of your own castle, again. We’ll show you how it can immediately ameliorate symptoms, while preparing the gut for a permanent fix, with special emphasis on a lean, healthy body. Deus Vult! The Basics It basically works like this. The Western lifestyle, including diet, lack of exercise, and alcohol use (and, in all likelihood, genetics, though the data just isn’t there, yet) leads to an imbalance of the bacterial composition of the gut (1,2). This results in the excess production and release of inflammatory signals, such as Lipopolysaccharide, TNF-alpha, interleukins, and prostaglandins, which subsequently escape the gut and enter the rest of your body (3). Though, they all contribute to the pathologies we will cover in various ways, it is Lipopolysaccharide (LPS) that we will focus on the most. Within the gut, this leads to the general digestive issues and inflammatory bowel syndromes like IBS and colitis that you have commonly known probiotics as being used to alleviate (4). While fixing digestive disorders will come along for the ride, our primary focus is going to be on body composition and metabolic health. In other words, we want to make you leaner, protect against diabetes, and help keep you from having a heart attack or stroke. However, there really is so much more to it than that, as a few quotes from the literature aptly demonstrate: “Changes in the composition of the gut microbiota (dysbiosis) may be associated with several clinical conditions, including obesity and metabolic diseases, autoimmune diseases and allergy, acute and chronic intestinal inflammation, irritable bowel syndrome (IBS)…” (5) “In this milieu… disturbance of the gut microbiota balance and the intestinal barrier permeability is a potential triggering factor for systemic inflammation in the onset and progression of obesity, type 2 diabetes and metabolic syndrome.” (6) “Through these varied mechanisms, gut microbes shape the architecture of sleep and stress reactivity of the hypothalamic-pituitary-adrenal axis. They influence memory, mood, and cognition and are clinically and therapeutically relevant to a range of disorders, including alcoholism, chronic fatigue syndrome, fibromyalgia, and restless legs syndrome… Nutritional tools for altering the gut microbiome therapeutically include changes in diet, probiotics, and prebiotics.” (7) As you can see, alterations in the microbiota can affect basically everything, but that there is also hope for change. Getting back to the gut and body composition, the aforementioned Lipopolysaccharide (LPS) leads to overactivation of cannabinoid receptor 1 (CB1) within the gut, which causes an increase in intestinal motility (speed of food going through) in the proximal parts of the intestine. This leads to less absorption of nutrient feedback signals that tell the brain you are well fed, and that it is time to stop eating (8). Concurrent with this is an increase in transit time in the colon, which results in a greater total harvest of caloric energy from your food (9, 10). In other words, the signal your brain is getting is that you are not getting enough food, while you are actually extracting more calories from what you eat. This not only directly leads to more fat accumulation from harvesting more calories, it lends itself to over-eating. This aggravates the cycle further, as overeating and increased adiposity are themselves inflammatory. So, what you have is more inflammation, more dysfunction, greater food intake, greater extraction of food, more fat accumulation, then REPEAT! The carnage does not even end here. Along with this inflammatory state is a disruption in the intestinal barrier. Intestinal permeability is increased and these inflammatory agents spill out systemically. This is often called a “leaky gut”. This results in a low-level inflammatory state in the entire body. The biggest culprit here is, once again, LPS (11). LPS activates CB1 receptors in the body and brain, just as in the intestine. In the fat tissue, this leads to activation of PPAR-gamma, and an upregulation of triglyceride synthesis, fat cell formation, and fat storage (12). In the brain, activation of CB1 increases orexegenic pathways, thus increasing appetite, hunger, and ultimately, food intake (13). This should not much as much of a surprise considering “the munchies” that accompany intake of famous cannabinoid receptor agonist, marijuana. And, LPS is not done yet, not at all. It also activates Toll-like Receptor 4 which, along with other inflammatory signals (TNF-alpha, interleukins), promotes both insulin and leptin insensitivity, peripherally and centrally (14, 15). At this point, your adipostat (the thermostat for your body fat level) is wrecked. Your ability to control food intake is gone, and you are a fat storing machine. Obviously, this is not what you want your body doing to itself. It is not what you want it doing to you. It is not what you want it doing to your life. Oh, and to top it off, atherosclerosis, heart disease, and stroke are promoted by these same inflammatory pathways. Combined with the increased body fat and insulin resistance, you officially have all of the perfect ingredients for the dreaded Metabolic Syndrome (16, 17). And, it is just a bunch of microscopic bacteria that call your gut “home” causing all of this devastation. See "References" here http://neobium.org/product-line/shock-therapy/#1 for references.
  5. What happened to everyone? 3+ years later?

    Test of Copying a thread from the Archives and making active...
  6. Still lurking here myself......M&M is good for old bastards........but other forums cropped up since the hay-day of Avant and people dilluted. But we still come back to the old tried and true form time to time.....this is the beginning for me.....started here so I will always come back
  7. What happened to everyone? 3+ years later?

    Thanks. I've been wanting to get back into it. I've been teaching chemistry at Humboldt State University full time and I'm also the COO (operations) of a solar thermal manufacturing facility. I am busy all the flippin time, but I still want to get to the gym more often now that the semester is over. I kindof want to re-learn what I once knew besides "do deads squats and dips and STFU" which is pretty much what the last few years looks like. Anyways since i'm probably writing into thin air i'm outta here. See ya at mindandmuscle
  8. Mind & Muscle is the old avant essentially; you should head over there. This is the first time I've been on Avant in probably at least 5 months but wanted to look at some old threads. www.mindandmuscle.net/forum
  9. ..been wondering the same. there seems to be such little activity here on the boards lately. i somehow managed to graduate with a degree in comp sci and have been working for the past 3 or so years in software. recently transitioned into product management. I've been living in the sf bay area for the past 2 1/2 years and am loving it. weights are only a minor part of my life now, as i've found that in this area there are many, many, many other things one can do that are just as, if not even more enjoyable- rock climbing, hiking, kiteboarding, surfing, etc. ]
  10. I used to frequent this forum if some of you may recognize the handle. I've hardly found time to dick around on forums since them. Just curious where everyone went. This used to be a very active forum. Just curious where everyone goes, and what everyone who was around a few years ago are doing these days.
  11. What happened to everyone? 3+ years later?

    First time back on the board in ages... Why so few Avant products now?
  12. Checking in

    Turning 15 in a few months... just started driver's ed. Can't wait to get my permit. Just stopped by, thought I'd say hello, and have a few laughs (or maybe face-palms) at some old threads while I was at it. Haven't seen any posts in a few years. Anyone still around? Have all the cool kids moved to another forum?
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