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mallela

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About mallela

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  1. Forskolin topical for tan?

    i am here with providing copy paste from PASPCR news letters september 2006 volume 14 number3--- start of copy---John D’Orazio discussed the induction of eumelanin synthesis in mice that lack functional melanocortin 1 receptor (mc1r) expression using topical application of forskolin. Melanocytes from these mice are unable to respond to melanocyte stimulating hormone due to the lack of the receptor. In humans, reduced activity is a risk factor for melanoma. Forskolin bypasses the receptor by inducing production of cyclic AMP and thus stimulating melanogenesis. Pheomelanotic mice were found to produce eumelanin following topical application of forskolin, which protected the mouse skin against UV-induced damage. While forskolin itself may not be useful as a topical treatment in humans due to its effect on multiple pathways, the group is pursuing the use of other molecules with similar properties.---end of copied material ============================================== Are there any trails on human skin for repigmentation of hair or skin tan with double blind controls .
  2. Forskolin topical for tan?

    i am here with providing copy paste from PASPCR news letters september 2006 volume 14 number3--- John D’Orazio discussed the induction of eumelanin synthesis in mice that lack functional melanocortin 1 receptor (mc1r) expression using topical application of forskolin. Melanocytes from these mice are unable to respond to melanocyte stimulating hormone due to the lack of the receptor. In humans, reduced activity is a risk factor for melanoma. Forskolin bypasses the receptor by inducing production of cyclic AMP and thus stimulating melanogenesis. Pheomelanotic mice were found to produce eumelanin following topical application of forskolin, which protected the mouse skin against UV-induced damage. While forskolin itself may not be useful as a topical treatment in humans due to its effect on multiple pathways, the group is pursuing the use of other molecules with similar properties. ============================================== Are there any trails on human skin for repigmentation of hair or skin tan with double blind controls .
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