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Separating Naloxone from Buprenex

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Suboxone tablets are a combination of 2mg. Naloxone, a potent opiate antagonist, and Buprenex, a partial agonist/antagonist.

 

They make 'em this way so that people don't abuse the meds, crush upand snort/shoot, etc... The naloxone is not orally active while the suboxone is slightly orally active. Thats why shots of suboxone are 0.2mg, while the tabs are 8mg.

 

I want to separate the naloxone for two reasons. Someone close to me (not me this time) has a heroin problem, and I want to make a sterile solution of naloxone in case she OD's so I don't have to take her to the emergency room and deal w/ the cops. In the words of Biggie: "I just got out, ain't tryin to see central bookin'" Reason 2: w/ pure buprenex, I can catch a nice little buzz.

 

Do any of you chemists out there know of a good way to separate the two?

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I like Buprenorphine; it gives a nice little high. All you need is 4 sublingual tabs and it lasts all day. It’s a great appetite suppressant and many competitive bodybuilders are using buprenorphine and or Nubain to suppress hunger and relieve pains when they train.

 

http://designer-drugs.com/

 

I read that Buprenorphine is very soluble in water. Try Simple cold water extraction.

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I read that Buprenorphine is very soluble in water.  Try Simple cold water extraction.

 

Bup is VERY soluble in water, even cold water. Problem is I can't seem to find any info on its solutiblity that's one reason they chose it over naltrexone in the fomulation.

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"Buprenorphine hydrochloride is a white powder, weakly acidic with limited solubility in

water (17mg/mL). Chemically, buprenorphine is 17-(cyclopropylmethyl)-α -(1,1-

dimethylethyl)-4, 5-epoxy-18, 19-dihydro-3-hydroxy-6-methoxy- α -methyl-6, 14-

ethenomorphinan-7-methanol, hydrochloride [5α, 7α(S)]-. Buprenorphine hydrochloride has

the molecular formula C29 H41 NO4 HCl and the molecular weight is 504.10."

 

"Naloxone hydrochloride is a white to slightly off-white powder and is soluble in water, in

dilute acids and in strong alkali. Chemically, naloxone is 17-Allyl-4,5 α -epoxy-3, 14-

dihydroxymorphinan-6-one hydrochloride. Naloxone hydrochloride has the molecular

formula C19 H21 NO4 HCl .2H2 O and the molecular weight is 399.87."

 

Source: http://www.opioids.com/buprenorphine/subutex-suboxone.pdf

 

 

Now, the only way I see to isolate the buprenorphine is by it's weight or use about 17mgs of buprenorphine in 1 mL of water and somehow seperate the naloxone...but I dont see how to isolate the buprenorphine if naloxone is so water soluble....

 

Any help would be greatly appreciated.

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